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Road trip from Seattle to San Diego

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My wife and I are Brazilians, in the early 30's, and we are going on a road trip starting Feb 20th from Seattle to San Diego. We have 12 days to do the trip and we are wondering what are the must see places and must do things on Highway 101, the cities near by and places and near the highway. Anything more than a 3 hour drive out and away from the hwy 101, we would try to avoid.

If someone has any tips that could give us, it would be greatly appreciated.

Dan & Gabi

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