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Raliegh, NC, Charleston, SC to Florida

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Traveling from Raliegh,NC to Charleston, SC, then on South along the Eastern Coast of Florida around mid-February for a couple of weeks. Will then cut across Flordia continue up West Coast area on up towards TN to visit friends. Have never been on East Coast between Charleston NC and Fort Pierce, FL so looking for information on that area. Love historical areas, antiques, nature, good food, small Mom & Pop cafes, beach areas (even if its cool out), etc. Not interested in golf or resorts. Our schedule will be very flexible, willing to drive a little off road to see an interesting site. Any suggestions on areas that you have found interesting on your travels in that area? Are most things open year round in those areas?

Looking forward to your suggestions.

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