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Portland to San Francisco with children

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My family of five ( 2 adults and 6, 8 and 10 year old dds) will be travelling from Portland to San Francisco during the first 2 weeks of July. We will be leaving Portland on 7/6 and heading south. Currently, we are planning on driving to the coast, enjoying the sand dunes and sites for about 3 days and then heading south. My question is, should we return the car and get on Amtrak on 7/12 and take the train to SF or should we skip the train and drive to SF? If so, what route to take?. We would like to arrive in SF no later then 7/13. If we drive, we are interested in any of the following: the Rouge River, Crater Lake, the Redwoods. However, any fantastic hotel for children just to relax at along the way would be great, too.

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