by wine county you mean Napa/Sonoma?

Yes -- we'll do research to figure out which specific wineries we'd like to visit when we know how long we've budgeted to spend there.

Oregon has some nice wine country as well.
The Oregon coast is nice but you could cut east to see Crater Lake NP. Cut east at Reedsport on 38 and see the Dean Creek Elk viewing area. Continue east on 38 to Elkton and take 138 which will bring you out on I-5. Take 138 east out of Roseburg up the Umpqua River past Diamond Lake to get to the north entrance of Crater Lake. When leaving the south entrance, you can choose to go west on 62 to get to Medford or east to get to US 97 which takes you back to I-5 at Weed CA.
Take a look at more of Oregon than just the coast.

Not sure how much time you have, particularly for your trip down the Oregon coast. What's your situation?

We could take up to two weeks, but I didn't want to take off work more days than necessary. Planning for the last two weeks or so in October.

@tomfuller you're right -- I do like Oregon wine but just forgot about it when faced w/ Napa and Sonoma. And your thoughts about traveling through Oregon sound great.

Two weeks is great! I like your plan, especially the leisurely trip down the Oregon Coast. You will love that. We loved the Oregon Caves. There's a National Park Lodge you can stay in there. I'm not too wild about Crater Lake, though everyone else seems to be. Hope you are planning on taking route 1 down the California Coast, esp between SF and LA. How can you go wrong with that itinerary?

How are you getting from SF to LA? I would take at least 2 days (3 is better) and stay in either Monterey or Carmel for one night, another night in Cambria or Pismo Beach and a third night in Santa Barbara. There are some lovely (and less expensive tasting fees) both in the Paso Robles area (just inland from Cambria a short distance) and the Santa Ynez Vally (north and inland from Santa Barbara).