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Napa vs Sonoma - Need Advice

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Next October will be our first trip to northern California. We are considering one night on the coast north of SF, five nights in Napa or Sonoma followed by three nights in SF. Is five nights in wine country too many? We are thinking of the Mission Sonoma Inn or the Harvest Inn. Is it crazy to stay two nights in one and three in the other. I like the idea of staying put for five nights in one place. If you stay in one place, are all the other areas accessible for day trips or is it too much driving? Also, can someone suggest a quaint, pretty town for one night north of SF on the way to Napa/Sonoma?
Thanks so much for any advice!

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