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ISO Best route to take from Iowa City to O'Hare

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Can anyone tell me the best (fastest) route from Iowa City to O'Hare on Monday? I will be driving to meet a 3pm domestic flight.

Should I just take 80 to 88? Someone suggested that I take 80 most of the way because of road construction on 88, but that seems like it will keep me pretty far south.

I will also be dropping off a rental car. Any suggestions for what time I should I plan on leaving Iowa City?

TIA for your comments.

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