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How to see coast and wine country from San Francisco in 4 days?

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My husband and I are spending our 20th anniversary in California in mid May. We plan to spend 2 nights in San Francisco then rent a car and head to the wine country. We have heard such great things about the coastal drive and would love to see the coast but don' t want to spend to much time driving because of our limited time. We have an additional 4 nights planed after we leave San Francisco and thought we might spend the first night on our way to wine country on the coast but not sure if it is worth the drive or if we should spend our 4 nights in wine country. We have heard Mendocino is nice but seems to be a long drive. Any thoughts on this would be greatly appreciated!

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