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Hey drivers, taking my grandmother to San Fran - lil help?!?

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Howdy do drivers. Im taking my elderly grandmother to San Francisco for Christmas. Its going to be a wonderful journey and we will be able to at long last distribute my grandfathers ashes. But my trouble is this: which route is best??
I am leaving from Los Angeles on either the afternoon of Christmas Eve or perhaps a bit earlier to avoid traffic. I want to get there in time to watch the sunset over the bay (oh baby I can cruise!). The 5 was a route suggested by a seemingly decent chap I met recently but I really dont know him that well and Im just not sure its safe (with an 82 year old female in the car and considering all the carjackings these days Im VERY concerned). A close (and TRUSTED!) family friend then suggested the 101 as a much more scenic route that would be free of criminal elements, get us there on time and provide delightful views the ENTIRE way. But my concern with this is that my grandmother gets frightfully car sick (don't even ask about our post thanksgiving meal journey from Encino to Six Flags - thats not gravy!). I know that her condition can be mitigated with sedatives/sleeping pills, but then she wouldn't enjoy the scenery.
So heres my question: Take the 5 to San Fran and risk something terrible happening at the hands of car jackers, OR: take the 101 and risk staining the seats of my brand new PT Cruiser with you know what (urgle gurgle). Can I combine the two somehow to beat the odds? Scenic + vomit VS fast + criminal element exposure.

Lil Help from all you fellow drivers? Pls advise....

Cheerio

"RGD"
Really Great Driver

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