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Driving from San Diego to Phoenix: Best way to go?

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I'll be heading actually to Mesa,Az (suburb of Phoenix)...heading eastbound on I-8....thru Yuma. Should I then take Hwy 85 north, or continue on I-8 and instead take Hwy 17? I'll be leaving San Diego probably around 9am Friday March 14.

thanks for any comments/suggestions!

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