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Driving Boston to Columbia SC

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My sister is moving in a few weeks and will be driving from Boston to Columbia. My guess during the end of November, she should stay on I95. I'm assuming the chance of snow is high along I81. Please correct me if I'm wrong.

Which route would you take and where would you stay? I know Rocky Mount is a common stopping point. Any other good options? They want to do the bulk of their driving on day one.

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