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Drive from MDW (Chicago Midway) to Iowa City

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Based on roadwork, traffic, etc., can anyone recommend the best route between these two points? I arrive MDW at 4pm on a Friday, and will begin my drive to Iowa City as soon as I get my rental car.

I'll be driving back to MDW from Iowa City on a Monday morning for a 6pm departure. I've taken both 80 and 88 before, but it seems like there's always something going on with one or the other. Thanks for any suggestions.

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