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Day Trip from Key Largo to Miami

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We are planning to stay for a week in Key Largo and take a day trip on one of our days to Miami South Beach. Has anyone done this? Is this a workable day trip? I'm thinking it would be like a day trip from L.A. to Palm Springs or L.A. to San Diego. Any additional info would be appreciated. By the way, we will have our own rental car.

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