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Charleston, SC - Help!

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I'm planning on flying into Charleston this summer to visit. I need help on a few things:

(1) Is it necessary to rent a car if I'm there for a 3 day weekend?
(2) Can anyone recommend hotels in the city that is centrally located?
(3) Is it difficult to get from the airport to the city/hotel area? What's the best way?

Thank you!! I'm a 26 year old from Boston, looking to possibly relocate!

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