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Charleston Lodging - West Charleston or North/Airport Area?

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We're doing a road trip from the Midwest to Charleston at the end of March and I plan to book our hotels through Hotwire as we go. We'll stay 3 days in Charleston and do day trips around the area. My elderly parents will be with us so keeping hotel costs down is a priority. Here's my question:

I can get a 2.5 or 3* hotel in the Hotwire North/Airprt area for about 30% less than a 2.5 * hotel in the Hotwire West area. That said, the dollar amount isn't that substantial. Is one area much better/more convenient than the other? Any insight you can provide would be appreciated.

Thanks!

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