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Best way to drive through Louisville?

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I'll be driving down I-65, heading south, and wonder which is the best route through Louisville.

I've been told that I-265 is too far around, and to take I-264. Is this the best way?
And which way around on I-264. The person lead me to believe I should go around to the east, but to the west seems shorter.

It will be on a Friday, possibly late afternoon, in Feb.

Thanks for any advice.

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