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Best hotel location in San Francisco?

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I've been to San Francisco several times, so I should have a stronger opinion, but either I can't remember or I just can't decide. Putting aside cost considerations, which area would you prefer for a 3-night stay (2 full days, given how the flight works) in late December? I'm stopping over on the way to Oaxaca, Mexico. Being near easy public airport transportation would be nice, but it's not a dealbreaker.

I'll be interested in the usual: theater, sightseeing, museums, galleries.
Last time I attended a theater production in the Mission district, but I doubt it's the preferred area to stay.

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