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Traveling with refrigerated medications

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My son needs to have medications that are refrigerated (but not frozen).

We are traveling from USA to Greece in about 2 weeks and were looking for tips on how to carry these on the plane, during travel in the car, etc., etc.

When we traveled last we used a small plastic container where we put the meds and then used freezer packs on the outside of this to keep everything cool but not frozen (since freezer packs were not touching the meds themselves - they were in a container).

But after about 4-6 hrs of travel things started to warm up - here we have up to 24 hrs of travel before we can get to a hotel with the refrigeration.

Separately, any tips on traveling with meds in the car? Assume it's really hot outside, would it be a cooler with ice packs?

There are some car coolers with a cigarette lighter but I am getting mixed reviews whether they work or not (some say they cool within only specific degrees from the outside temperature). Are there any 'portable refrigerators' or close to that?

Thank you

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