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Rehoboth DE to Charleston SC

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I would love some advice for an upcoming road trip my husband and I are taking. We are driving from Rehoboth DE to Charleston SC and staying a very short time but flights were over 450$. Our plan is to leave Friday night and stay in VA and get up early for the drive to Charleston on Sat. go to a wedding and head halfway home Sunday night. I would love to hear some ideas on what we must see in Charleston and a good place to eat and any advice on where to stay on the way home, a good halfway point. Thanks

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