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italy itinerary

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My husband and I are planning a vacation to Italy in May and it is our first European trip . I am considering flying to Venice and spending 2 nights, taking the train to Vernazza in Cinque terra and stay 2 nights and then rent a car and stay in a farmhouse in Tuscany (maybe Montepulciano ) for maybe 6 nights. Where would be be the best place to rent a car? Could we pick up one in Spieza and drop off in Florence? Any difficulties doing this on our own without knowledge of the language? We are more interested in beautiful scenery, photography and good food and wine. Will a daytrip to Florence be enough?
Is Montepulciano a good area to base ourselves? There are so many beautiful farmhouses to chose from. We are 65 and 60 and in good shape. Any suggestions would be appeciated!

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