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What to see and do in BioBio region?

I am planning to travel to Chile for about 8 to 12 days in late July / early August. I am planning to spend first few days around Santiago and Valparaiso, but after that I am thinking to go south.

Should I consider BioBio region as part of my trip? Is there anything worthwhile to see or do there? I guess say Concepcion, Bio Bio valley or some of those smaller towns near by.

Also, depending on above...Would it be worthwhile and feasible to rent a car and drive south by Pan American high way? (possibly after I get done with seeing Santiago).

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