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what to carry going to different countries and vaccinations

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Hello good people:

My son is going next week to different countries in South America for a year. He is going to work as a volunteer in different medical clinics in some rural areas and some cities( he is a medical student), and travel a little. He may be taking just one big suite case or one big backpack , (WHAT IS BETTER?), he will be staying some times with families some times in hotels

Any suggestion as for what is a MUST to take there as he keeps saying that he does not want to carry much and he will buy there if he needs . He is taking malaria pills, anti biotics and he took yellow fever shot.

I am really worried that he may not be well prepared.

Any advice please write

Thank you all

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