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Touring multi-countries on Bus - Am I Crazy?

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Hi, I am single and have travelled many countries in several continents, but none in South America. My retirement is approaching so the time will not be an issue anymore. Since I have time and so many countries I would like to visit, I an thinking about flying into, say, Quito, for example, and tour the South America large cities an small over two months on buses between the cities and the countries. The countries I would like to visit include Ecador, Peru, Chile, Argentina, Brazil. Am I crazy? Or is it doable in terms of availability of inter-country bus lines and safety of this type of travel on buses? I am thinking of carrying a 50 Liter backpack and utilize airbnb type accommodation whenever possible. I have been learning Spanish over year and a half using Pimseuler method. Going to Spain for 6 weeks this April, and that should help. Any advices, thoughts, or comments?

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