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Skip Sao Paulo, a mistake?

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I am working on an itinerary to South America. I intend to fly to Rio and from there make my way down to Iguaszu Falls. I am debating if I should just fly from Rio to the falls or I should make it a point of visiting Sao Paulo. SP sounds like a business city with little in the way of tourist attractions. If I add SP to the itinerary I will spend two days/three nights there after spending five full days in Rio. Is SP worth the effort? If so, how should I travel to SP from Rio, by air or by bus (maybe via Paraty, Paraty is not a priority the only reason I mention it is to break up the travel time between Rio and Sao Paulo). The Brazil portion of the trip will end in at the falls from here I will travel to Argentina, to continue my trip to South America

Any comments/thoughts on Sao Paulo from fodorites who have been there will be appreciated. Thanks.

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