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Santiago neighborhoods for apartments in Dec./Jan.

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My husband and I are traveling to Chile late Dec - early January. We are taking our nephew, a collage student . We are looking at 2 bedrooms in AirBNB.
We are looking at an apartment - for our time in Santiago that is near La Universidad de Chile and would love feedback on that neighborhood. If people do not think it is a good neighborhood are their other locations you would recommend. We will be going to museums and a day trip to a vineyard (red wine) while in Santiago, so near public transportation is valuable.