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Rainforest in Peru: Iquitos, Puerto Maldonado -- what's the diff?

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These two places seem to be the major jumping off points for rainforest adventures in Peru.

If I could only pick one, and given that I would like to stay in a *relatively* confortable lodge (something with privacy, good mosquito netting, great trails, informed guides and good food)which one should I pick?

In other words, what is the difference between these two places, their accomodation options and the viewing they have to offer?

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