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Peruvian Amazon Basin - Iquitos or Manu?

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I'm planning a 11 - 15 day trip to Peru - likely 4 days in Cuzco/Machu Picchu, a day in Lima and the balance in either Iquitos or Manu, mid summer 2013.

Any viewpoints on preference between Iquitos (either jungle lodge or river cruise) and Manu Reserve would be greatly appreciated. I'm leaning toward Manu as the jungles seem more remote and it is a little easier to get to from Cuzco.

Thanks.

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