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Help with our South American Itinerary please.

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I have been reading a lot of the trip reports but still unclear as to how to proceed with our own trip in January.
My husband and I are in our late 50s/mid 60s. We travel middle of the road style and will have one carry on bag between us and two day packs.

We are leaving Vancouver on Jan 5th for Santiago Chile. We will spend two weeks exploring Chile before our cruise leaves around the Horn to Buenos Aires. Upon arrival in Argentina we will spend about two weeks seeing, not necessarily in this order, Igassu Falls, Rosaria and Salta. We will rent a car for part of it. This takes us to Feb 15th or so.

We will be in Equador from March 10th to 15th or so to April 5th, so we have almost month to fill in. This are our thoughts of options, but this is where we need some expertise to guide us.

1.From Igassu go into Brazil and explore there. Fly from Rio to Quito.
2. From Igassu go into Paraguay and fly from Assuncion to Quito
3. Continue north from Salta into Bolivia by bus/train. This is where I am not sure about bus service through the Andes, and how easy and comfortable this trip would be. We would then fly from La Paz to Quito.

We dont want to do too many more flights, we want to keep the costs down. I looked at flying from Rio to La Paz and then Quito but it just keeps adding up.
I have already done Peru/Matchu and it was perfect so dont want to do it again. I have also done Lake Titicaca but my husband has not

We are doing an amazon tour in Equador so dont need to do one in Brazil.

Any advice is most welcome and appreciated. Thanks in advance.

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