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Help with itinerary

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So sorry that I am not totally up to speed with Argentina, but looking for people to push me in the right direction....

I am a fairly "young" 50-something female. I am taking my sister, who lives in downtown Toronto, to Argentina for her 60th birthday for about 11-12 days (upon arrival). Unfortunately she has a bad knee so significant walking/hiking is not going to work. We obviously plan to go to BsAs and will likely book accommodation through airbnb, but we don't want to spend all of that time in one city.

I am looking for itinerary suggestions. Should we go to Mendoza or the Salta area? Are both best reached by air or by other transport? Is there another spot we should stop in on the way there or back? Are either Cordoba or Rosario worth visiting?

I'm guessing that Iguazu is not the right place for us?

My sister used to ride horses (including modest horse jumping). Would it be worthwhile stopping at an estancia?

Thanks so much for any input!

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