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Bolivia: La Paz, Titicaca, Uyuni or Sucre w/Kids. Itinerary Help Wanted

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Family of 4 with 2 kids (12 and 10) traveling to Bolivia end of Feb/beginning of March for 2 weeks.
Flying into La Paz from Santiago de Chile.
Staying at Aparthotel a la Maison (Sopocachi Psje, Munoz Cornejo n.15,) for 3 nights
Want to go to Lake Titicaca, staying in Copacabana for 3 or 4 nights.
Have one week, trying to decide between Uyuni or Sucre.
Back to La Paz, day trip to tour Tiwanaku, fly out of La Paz to Lima.

Questions:
Is la Maison located in an area where we'll be able to walk around, find food stores, pharmacies, sites, etc., or will we need to take a taxi everywhere?
Can we see the sites in La Paz on our own or do we need to hire a guide? Top 3 sites not to miss?
Best way to transfer between La Paz and Copacabana? Tourist bus? Recommended bus companies?
Isla del Sol - worth it? Day tour or overnight(s)? I'm leaning toward a day or not at all
Hotel recommendations in Lake Titicaca? (Thinking Hostal Las Olas)
BIG Question: Uyuni or Sucre for 2nd week? We've heard fabulous things about the Salares, however, am concerned about the weather and getting stuck this time of year. Thoughts? Sucre seems really cool as well. We cannot do both.
Guides/tour company recommendations for Tiwanaku? We'd like to have a guide for the ruins. Would this be better to do on the front end? and just do a night near the airport for our last night (if that's even possible)?

About us:
We all speak Spanish at a decent level. We have traveled by bus through Brazil, Argentina, and Uruguay. We have lived in the jungle of Costa Rica and have traveled to Nicaragua (by bus) from there. We have also traveled in Peru and Chile. We typically stay in private apartments or aparthotel instead of hostels. With a group of 4, I'd like to have some plans loosely made, because it's often difficult to grab bus or airline seats for 4 last minute. Also, we typically like to stay in a place for at least 5 days to a week. That way, we get to know the city and the people. My husband had issues with altitude sickness (headaches mostly) during our last visit to Cusco, Peru, so we want to make sure we have enough time to take it slowly and acclimate in La Paz.

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