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Argentina Road Trip

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My husband and I will be in Argentina in August for about 10 days. Our "must sees" are Buenos Aires and Iguazu Falls. We'd love to do a road trip between them to see more of the rural areas, but I have some concerns that I'm hoping someone here can help with:
1. The distance is too far so we'll either fly one way or take the overnight bus. However, there is a huge penalty for a one way car rental. Any o ther ideas?
2. From what I have read so far, the really spectacular scenery seems to be more in the northwest and south (obviously in Patagonia!). Is the region between BA and the Falls also worth visiting?
Other suggestions on what we can do for a road trip? Another thought was to do a few days round trip road trip somewhere near BA, then just fly to/from the Falls to save time.
Thanks so much!

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