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Amazon from the Andes?

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We are planning a 3-week trip --- cherry picking some of the highlights in the northern Andes, not even sure if we'll make it to all three countries this time. We are interested in seeing Inca Ruins, colonial cities, indigenous markets and Lake Titicaca and hopefully, a short trip to The Amazon Basin rainforest. No Galapagos this trip.

Balancing the quality of the rain forest experience with the difficulties involved in making the excursion, would you access the Amazon from Ecuador, Peru or Bolivia? Where would you arrive and stay?

Any other insights about highlights of the region would be appreciated too. Thanks.

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