>>>Is it advisable to take Euro Rail to Roam from Barcelona and back?<<<

No. Euro Rail is some type of rail pass, not the actual train companies for these countries. The overnight train between Spain and Italy goes from Barcelona to Milan (only three days per week), not Rome.
http://www.elipsos.com/

I would stick to Spain instead of going all the way to Rome, but if you must go, look at budget flights.
www.skyscanner.com
www.whichbudget.com

There is also an overnight ferry between Barcelona and Rome's port Civitavecchia (an hour by train outside of Rome). The ferries will probably be much more expensive than a budget flight.
http://www.grimaldi-lines.com/

Hi!

Thanks a lot for the reply. Lets say if I were to stick to spain. What are the recommended cities to visit?

Thanks

Vueling has cheap flights all over Europe and Spain.
If you stay in Spain, you might take the train to Madrid for a few days visit

Or fly to Seville or Granada( to see Alhambra) and a bit of Andalucia
The south may be warmer....totally different than Barcelona.

Sevilla, Granada, Cordoba - I'd go south at that time of year.

If Rome is important to you, I would book a budget airline to fly from Barcelona to Rome on the 17th, so that when you move out of the conference hotel you'd just head directly to airport to fly to Rome. (Make sure you understand the luggage weight limitations on budget airlines.)

Then you may fly back to Barcelona on the 20th, that will leave you two and half days in Barcelona. And you would already have seen some of Barcelona between 13th to 16th.

There are Roman ruins in Spain if your wife wants to do a search. Also in the south of France..No need to travel to Rome.

Cool. Thanks a lot. I am also doing my search and it seems like it better to go to the south of spain or Paris, France. Perhaps I should leave Rome for another trip.

Flying Barcelona -> Sevilla is about the same distance/time/effort as flying Barcelona -> Rome.
One should go to where one's heart is set.

Ruins not far from Barcelona, in Tarragona, easily reached by train.

http://en.wikipedia.org/wiki/Tarragona_Amphitheatre

http://en.wikipedia.org/wiki/Pont_de_les_Ferreres

There are Roman ruins all over Italy, France, Germany, Spain and even the UK.

But if she really wants to see THE Coloseum and the Forum and the Pantheon, et al - then do go to Rome. But flying is the only way that makes sense (train would take an incredible amount of time). And Nov in Rome should still be not too chilly - they rarely get snow - even in midwinter never mind fall.

Is it too late to fly into Barcelona but out of Rome? That would save you the return trip.