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Two week Italy itinerary

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My husband and I are planning a 2 week trip to Italy in early May 2011. I'm a planner, so I've already been working on our itinerary. We are in our 40s, very active, no kids. Enjoy walking the city, biking, wine tasting, etc. We've been to Europe (mostly Spain) a few times, but this is our first trip to Italy. I'm looking for feedback on our overall itinerary, and I'd also welcome suggestions on affordable hotels (i.e., nothing fancy, just proximity and overall cleanliness/safety). I thought we'd start with Rome (more stressful) and end with Florence and Sienna (more relaxed).

Fri/Sat: Fly from Colorado to Rome; walk around Rome.
Sun: Colosseum, Forum, etc.
Mon: Day trip to Pompeii
Tues: Vatican City
Wed: Day trip to Oriveto
Thurs: Train (4.5 hrs) to Venice; walk around Venice
Fri: Tour Venice
Sat: Early train to Cinque Terre
Sun: Hike Cinque Terre
Mon: Train to Florence
Tues: Tour Florence (Uffizi, Academia, etc)
Wed: Join a bike tour in the Tuscany area (suggestions?)
Thurs: Take bus to Sienna; tour Sienna
Fri: Depart Sienna for Rome. (Enjoy a last day in Rome)
Sat: Morning flight home.

Whew! Any thoughts?

M

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