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Travel from Amalfi coast to Pienza

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My wife and I will be traveling from the AC to a small town near Pienza during the second week of September. The current debate for this trip is how to get from Priano to Pienza. Would it be better to rent a car in Sorrento or Naples and drive or take train to Perugia then rent a car and continue the trip? We will spend 7 nights in the Pienza area followed by 3 nights in Florence, where I would return car upon arrival, then take train to Rome for return to US. Any advice?
Thank you.

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