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South of France and Italy 10 Day Train Itinerary - suggestions?

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Hello! We are going to be three 22-23 year old girls and one girl's mother travelling this June. We would love to see lots of arts and culture, but we don't want to be in a stressful whirlwind of places - some relaxation is necessary. We love the idea of staying in or at least seeing some of Arles, Aix-en-Provence, or Marseille, but Nice seems lovely as well, and to be a better place transportation-wise since we don't want to waste all of our time transferring trains! Here are my three preliminary itineraries, based on the train routes. Which do you think seems the most viable? Do you have any suggestions on where we should spend more time or less, or another alternative to breaking up our train travel than in Cinque Terre? I'd love to break up that 7 hour train ride with a night somewhere, but I don't know if that will allow us enough time to go to Venice as well. Also, staying in 4 hotels over 10 days seems like a lot! I've never done a trip like this before - what do you think?

Option A: City in Provence, cinque terre, Pisa/Florence
Day 1: Fly into Nice - train to Arles/Aix-en-Provence/Avignon/Marseille (which one??) and settle in.
Days 2,3,4: Explore the city we stay in and do day trip to another
Day 5: Train to Nice, transfer to Ventimiglia, transfer to Cinque Terre - (there might also be a train direct from marseille to ventimiglia without the transfer in Nice, more research needed) Night in CT
Day 6: Explore Cinque Terre, stay the night again
Day 7: Train from CT to Florence by way of Pisa. In Pisa it seems like we can leave our luggage at the train station, go to the leaning tower and lunch for a couple of hours, and then continue on to Florence for the afternoon/night.
Days 8-9: Explore Florence
Day 10: Fly back to NYC from Florence!

Option B: Nice, Pisa, Florence, Venice (more time in Nice and Venice, less in Florence)
Day 1: Fly into Nice. Settle in, relax
Days 2,3,4: Explore Nice. Take a day trip to Antibes (picasso museum) and possibly Monaco (only 20 mins away!) Lots of day trip ideas/info here: http://www.fodors.com/community/europe/top-3-day-trips-from-nice-itinerary-help-please.cfm
Day 5: Nice to Ventimiglia (45 mins), ventimiglia to florence with a stop in Pisa (described above), evening in Florence
Days 6-7: Explore florence
Days 8-9: Take (2 hour) train to Venice. Stay 2 nights.
Day 10: Fly back to NYC from Venice! Is flying from Venice more expensive/inconvenient?

Option C: Nice, Venice, Florence, Sienna (Less time in Nice and Venice, more in Florence)
Day 1: Fly into Nice. Settle in.
Days 2-3: Explore Nice. Day trips as above.
Day 4: Nice to Ventimiglia (45 mins), Ventimiglia to Venice (about 6-7 hours). Evening in Venice
Day 5: Explore Venice.
Day 6: Morning train to Florence. Explore Florence.
Days 7-8: Explore Florence
Day 9: Day trip to Sienna or other, evening in Florence
Day 10: Fly back to NYC from Florence!

Thank you so much!! We all are really excited for this trip and want to book our flights right away, but we want to be sure we can maximize our vacation time!

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