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Scenic Route Between Rome and Florence as Alternate to High Speed Train

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Three of us will be travelling from Rome to Florence in March. Is there a reasonable alternative to the High Speed Train that will allow us to see more of the countryside? We were thinking of train but perhaps bus? Car rental just for that trip doesn't seem viable. If we travel by train, for example to Pisa then to Florence or to Siena to Pisa to Florence, what would we do with luggage while stopping to see the city? Can it be done in a relaxed day? It would certianly be easier to take the fast train but what would we miss that we could take in?

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