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Santender good base for Picos de Europa?

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In late April we'll be driving west from San Sebastian along Spain's north coast. Planning 2 nights in Santender. I'll like to dedicate one day to a drive to Picos de Europa and the other to explore Santender. .. Is a Picos drive doable in one day from Santender? I know ideally should dedicate more time, but 1 day is what I have. The guidebooks cover several scenic drives. What would be the best scenic drive in Picos to do in 1 day, ending up back in Santender to sleep? another option would be to do the drive the day I leave Santender on my way to Oviedo...but I plan to do Altamira and Santillana del Mar en route.
Appreciate your advise!

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