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Rome Subway

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I will be visiting Italy in early January. Our first stop is Rome and we will be staying near the Spagna Metro station. After that, we will travel by bus to Siena, and I have purchased tickets for a bus that leaves from Tiburtina at 6:30 am. I believe that the Rome Metro begins running at 5:30 am.

Would I be able to go from Spagna to Termini, switch to the B line and get to Tiburtina in ample time to catch the 6:30 am bus?

Thanks for your help!

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