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Rome and Tuscany Region in 10 days

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My husband and I will be going to Italy for our first time in May, 2013, for 10 days. We want to visit Rome and the hilltowns in the Tuscany region. We are thinking of going to an agriturismo in Montepulciano, as a home base for 5 days, (seeing San Gimignano, Siena, Civita di Bagnoregio,Lucca) and then going back to Rome for the remainder of our trip. Someone advised us not to rent a car from the airport but to take the train to the Tuscany area and then rent a car. Any thoughts? Also, is Florence a must see, and if so,
can we fit that in? We want our trip to be somewhat relaxing and enjoy the food,wine and people of Italy!

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