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Rental car travel from Amsterdam to Italy and back

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Hello -

My sister and I (both in 50s) are travelling for a week from Amsterdam to Zurich to Siena and back to Amsterdam. We are considering renting a car for this trip and looking at mapquest driving directions it looks as though it is doable. I don't mind driving but I am a little nervous about some of the crazy-sounding drivers in Italy. The train seems too expensive. Does anyone have experience driving in these areas and making a trip like this in 7 days? Are we crazy to try it?
Thank you!

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