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Perpignen to Tours, France - Scenic car route

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We're getting a cruise that finishes in Barcelona in September and then plan to catch a train to Perpignen and then drive a rental car over 3 days to Tours (or Lyon?) where we'll catch the TGV to Paris for the weekend before returning to London.

I've driven through France many times but my partner never has.

He is disabled due to replacement knees and can't walk to far or up/down too many hills/stairs so we'll need to stop in places that are reasonably accessible. We may think about renting a wheelchair for the trip to make life easier.

We've both been along the Cote D'Azure before so a trip through Provence is our preferred area - any suggestions as to a scenic route and places to go to?

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