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Paris to Loire Valley to Nice - drive, train or fly?

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This is our first trip to France and are very excited. We are traveling with our 4 year old. Here is our itinerary (April 19 to April 29) 4 days in Paris, 3 days in Loire Valley (our hotel is in Tours), 3 days in Nice (visiting relatives/family). We are planning on renting a car in Paris, drive to Loire Valley, back to Paris, then take the train from Paris to Nice. There are no trains or flights going to Nice from Tours. We are also considering driving to Nice from Loire Valley, and perhaps stop for one night along the way. Your comments/recommendations will be appreciated.

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