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Nice to Florence Bus or train?Help

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My husband and I are going to France and Italy in May. We are staying with friends in Nice and want to travel to Florence for 3 days , then onward to Venice and Rome. I have all transportation details except Nice to Florenc and Florence to Venice. My (Nice) friend says the overnight bus from Nice to Florence was the best way to go?Safer? Can't I just buy tickets when I get there or buy them before we go?For either train or bus?
Thanks for all your help!

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