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London to Rome in 10 days. Itinerary Suggestions, Please!!

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First time to Europe and a family of 5. Wanting to hit the highlights and see as much as we can. One of my kids wants to visit Holland while my girls want to see Paris. Would like to see Switzerland as well. Wife wanted to try and include Spain but geography may not allow that. Would like to travel by train. Any recommendations? Any must sees? Once in Rome we are taking a cruise to see Italy and Greece.thanks in advance

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