I'm not sure what the "etc" that follows Urbino stands for, but towns the west and north of Urbino, in the Montefeltro hills, are rich in interest and charm. Loreto, though by the sea, is one of the great art sights of the region.

But it is vary hard to craft an itinerary for someone else, especially since you haven't said where you are coming from to enter le Marche, and especially since the mountain range that sits in the of the region makes it hard to move around unless you include the seaside for covering some ground. If you have not already pored over the Marche Voyager website guide to all the towns and various itineraries you could take, then it describes more than can easily be done by posters here.

http://www.le-marche.com/

If you are driving north from le Marche to Ravenna, then San Leo is a spectacularly situated hilltown that is almost en route in you are coming from Urbino. The seaside town of Rimini (in Emilia-Romagna) has several noteworthy ancient Roman and Renaissance sites, plus various quirky shrines to Federico Fellini, who was born there. North of Rimini, the town of Cesenatico has a port designed by Leonardo da Vinci, and if you approach Ravenna from that southern coastal route, you can include a stop in Classe to see the brilliant byzantine mosaics in the basilica of Sant'Apollinare, which are an integral part of the historic mosaics of Ravenna.

We went to Le Marche last year and loved it so much we are going back this year. Our trip report and photos are here:

http://www.fodors.com/community/europe/jamikins-and-bikerscott-do-italy.cfm

I bought the Marche Voyager book and have high-lighted some of the things that interest me. They have some very good 1-3 day driving tours.
The link posted by goldenautumn above will take you to the website.