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Itinerary and Train advice

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This site is a wealth of information. Thank you!

Planning a last minute 21 day solo trip in mid-April. My main focus will be art and architecture. I am not a fan of flying. My tentative itinerary is as follows:

London (3 nights) Eurostar to Paris
Paris (6 nights) Train (TGV or Thello to Milan or Florence)
*Milan (1 or 2 nights?) train to Florence
Florence (4 nights) train to Rome
Rome (5 nights) flight to London
London (1 night) flight to NYC (already booked)

Advice regarding itinerary?

Paris to Italy train: TGV or Thello? TGV arrives late in Milan. Should I stay in Milan or is the night train to Florence a wise choice for a female solo traveler? Does it make sense to stay in Milan for two nights? Is the Thello the better choice? I have read mixed reviews about Thello. If I went this route, I would get a single cabin. Any advice?

Planning to be in either Florence or Rome during Labor day. Which would be better?

Thank you!

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