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How to keep medication refrigerated while traveling?

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One of my travel friends now has to take nightly eye drops which require refrigeration. She is concerned about keeping it refrigerated on those travel days which combine both long flights and then travel by train or car. I'd like to know how others have solved this problem or do you modify your travels to suit your medical needs. Just wondering if we now will have to find hotels that have mini bars rather than our usual charmingly quirky two star hotels without ;;) Thanks for any suggestions I can give her. Deborah

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