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Help! Swiss-Italy train - Lausanne to Milan ending in Rome. Hotel ideas!

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Dear Fodor Community:
This is our first trip to Switzerland and Italy together for my wife and I, although I have been to Zurich and Rome earlier on business trips. I am attending a conference in Lausanne from July 22-24, and then we plan to travel south by train across the Swiss border into Italy visiting four cities. We fly into Geneva on July 21, take a train to Lausanne, stay at Movenpick Hotel, check out on July 25 - plan on taking a train to MIlan, perhaps stay there for a day (Lake Como is very tempting but not sure if I can do it!) and then by train to Venice, stay for two days, train to Florence, stay for two days and then finally Rome for three days.

Can you please help advise me on few issues? Is it cheaper to book the Swiss train from Lausanne to Milan for July 25 travel right now from here in the USA? Any helpful pointers for my wife to tour around Lausanne while I am at the meetings? For our ten day, four city trip through Italy, should I buy the Italian Railpass from here in the USA (is it cheaper if bought online in the USA)? Should we reserve our seats in advance?

Finally, any advice on staying at hotels or apartments in Italy? A friend of mine suggested http://www.romesweethome.it which lists many private apartments for rent in Rome and other cities in Italy and seems less expensive than hotels. Any comments from users?

Can you please suggest some hotels around $1201-$150 range in Milan, Venice and Florence that is closer to the city centers and the train station. I am trying to convince my wife to pack light and carry a back pack as I remember train stations in Europe often require lugging the luggage through stairs. Am I correct?

This is a great forum that I have stumbled and learned so much already. Thanks!

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