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Getting from Prague to Bayreuth

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Hi, everyone. We need some suggestions for getting from Prague to Bayreuth in mid-August. Is the easiest and fastest way to take a bus from Prague to Nuremberg and then the train from Nuremberg to Bayreuth, or is there a quicker, more-direct way (other than driving) that I haven't been able to find? Going entirely by train seems to take much longer. Is that correct?

Also, can anybody comment on the general conditions and comfort of the buses from Prague to Bayreuth?

Thank you for your help,
Dave

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