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Florence/Siena, Stay in Florence or both?

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We will be in Italy the beginning of Oct for 18 days and roughly our itinerary is as follows:

Rome - 4 nights
Siena - 4 nights
Florence - 3 nights
Cinque Terre - 4 nights
Venice - 3 nights

We will not be renting a car but will be using buses and trains as our means of transportation. Our original plan was to use Siena as a base to visit some of the towns such as San Gimignano, Cortona, etc. and then from Florence possibly Pisa or Lucca. Now I am beginning to wonder if it would just be better to go to Florence and use that as our base for exploring.

Would it be easier to get in and out of Florence to these smaller towns or should we stick with our original plan. Or perhaps the experts on this forum have another suggestion!

Thanks!

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